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Clinicians should be aware that while nutritional supplementation is beneficial, there may be upper thresholds beyond which no added benefit (or even potential risk) occurs

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Protocatechuic acid (PCA), one of the major metabolites of antioxidant polyphenols, has a strong antioxidant effect on cells, an antiproliferative effect on tumor cells, and a protective effect against neuronal apoptosis after cerebral ischemia [75]